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. 2013 Feb;141(2):261–272. doi: 10.1085/jgp.201210885

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© 2013 Jin et al.

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Figure 1. — Model of drug convection–diffusion in intestinal crypt–villus units. (A) Schematic of epithelial cell–lined crypt–villus units (lengths, L_crypt and L_villus). Fluid secretion into the lumen produces convective (upward) solute transport. (B) Three-dimensional model of radially oriented crypt–villus units projecting from a cylindrical lumen. (C) Section near the intestinal wall showing crypt–villus units and a wedge of luminal aqueous-phase volume. Cylindrical symmetry reduces computation complexity. An example of pseudocolored inhibitor concentration profile is shown.