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. 2013 Feb;141(2):261–272. doi: 10.1085/jgp.201210885

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© 2013 Jin et al.

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Figure 3. — Convective inhibitor washout requires a very high concentration of a membrane-impermeant inhibitor in the intestinal lumen for antisecretory efficacy. (A) Computations done for human mid-jejunal anatomy as in Fig. 2. Percent inhibition of net secreted fluid as a function of C_o/K_d for indicated J_v^o. J_v^o of ∼7 × 10⁻² µL/cm²/s is typical in cholera. (B) Computations done for human colonic anatomy with long, narrow crypts without villi. Percent inhibition of net secreted fluid as a function of C_o/K_d for indicated J_v^o. J_v^o of ∼7 × 10⁻³ µL/cm²/s in colon is typical in cholera.