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. 2013 Feb;141(2):229–241. doi: 10.1085/jgp.201210870

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© 2013 Gustina and Trudeau

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

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Figure 9. — Model of eag domain interaction with the channel. (A) Schematic of WT hERG showing eag domain interaction with the CNBHD and a proximal domain, which is continuous with the transmembrane regions. (B) Schematic of hERG Δeag plus N1–135 showing eag domain interaction with the CNBHD and a proximal domain, which is continuous with the transmembrane regions but not attached to the eag domain. (C) Schematic of hERG ΔN plus N1–354 showing eag domain interaction with the CNBHD and a proximal domain, which is continuous with the eag domain but not connected to the transmembrane regions.