Table 2.
Construct | V1/2 | k | n |
mV | |||
hERG | −68.69 ± 2.24 | 19.51 ± 0.50 | 9 |
hERG ΔN | −59.60 ± 0.73a | 25.72 ± 0.32b | 8 |
hERG ΔN + N1–135 | −74.15 ± 1.67 | 19.51 ± 0.34 | 10 |
hERG Δeag | −60.97 ± 1.65a | 24.74 ± 0.56b | 9 |
hERG Δeag + N1–135 | −69.71 ± 1.70 | 20.35 ± 0.37 | 9 |
hERG ΔN + N1–354 | −68.68 ± 2.35 | 20.49 ± 0.64 | 10 |
Boltzmann fit values for V1/2 and slope (k). Values shown are the mean ± SEM; n indicates the number of cells.
P < 0.05 versus HERG WT (ANOVA).
P < 0.01 versus HERG WT (ANOVA).