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. 2013 Feb;141(2):161–164. doi: 10.1085/jgp.201210953

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© 2013 Dixon and Santana

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Figure 1. — Ca²⁺ signaling pathways regulating airway contraction. Summary of the major Ca²⁺ signaling pathways involved in regulating MLC phosphorylation and airway smooth muscle contraction. 5-HT, 5-hydroxytryptamine; ACh, acetylcholine; CPI-17, PKC-potentiated inhibitor protein of 17 kD; DAG, diacylglycerol; GPCR, G protein–coupled receptors; IP₃, inositol trisphosphate; IP₃R, IP₃ receptor; LVGC, L-type voltage-gated Ca²⁺ channel; MLCK, myosin light chain kinase; MLCP, myosin light chain phosphatase; PIP₂, phosphatidylinositol 4,5-bisphosphate; PKC, protein kinase C; PLC, phospholipase C; PM, plasma membrane; rMLC, regulatory myosin light chain; ROCK, Rho kinase; RyR, ryanodine receptor; SERCA, sarco-endoplasmic reticulum Ca²⁺ ATPase; SOC, store-operated channel; SR, sarcoplasmic reticulum; STIM, stromal interacting molecule.