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. 2013 Feb;141(2):193–202. doi: 10.1085/jgp.201210919

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© 2013 Vanoye et al.

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Figure 4. — Effects of intracellular GTPγS on Na_V1.9 kinetics. (A) Time constants for activation in the presence of intracellular GTPγS (n = 13–14). (B) Time to peak current in the presence of intracellular GTPγS (n = 21). Dotted lines illustrate data for control solution (from Fig. 2). (C) Averaged whole-cell Na_V1.9 currents recorded during 300-ms pulses to −80, −60, −40, −20, and 0 mV. Dotted line indicates the zero current level (n = 10). (D) Inactivation time constants (fast, blue; slow, red) recorded in the presence of intracellular GTPγS (n = 8–14). Inactivation time constants for control pipette solution (open circles; n = 13–17) are also shown (from Fig. 2 D). (E) Fractional amplitudes for inactivation time constants determined in the presence of intracellular GTPγS for −40 to 10 mV (n = 8–14). Data are represented as means ± standard error of the mean.