Age-specific incidence rates (per 100,000) of primary liver cancer in men, Canada, 1980–2007. Primary liver cancer incidence was defined as C22.02. * p < 0.05 (statistically significant). aapc = average annual percentage change, calculated using the JoinPoint Regression Program (version 3.5.4: U.S. National Cancer Institute, Bethesda, MD, U.S.A.).