Table 7.
Gene Ontology functional annotation of proteins which were regulated in this experiment according to their involvement in different molecular function
| Molecular function | Proteins | CPX > RA | CPX < RA | CPX > c | CPX < c | RA > c | RA < c |
| Nucleotide binding | 41 | Hsp90ab1 | Atp5b | Tubb2a | Cct2 | Cct2 | Ldhb |
| Fkbp4 | Cct2 | Etfa | Tardbp | Hspa4 | Fkbp4 | ||
| Tubb5 | Tardbp | Hspa9 | Hspa4 | Myh9 | Tubb5 | ||
| Hspa5 | Hspa4 | Actb | Tuba1c | Nme2 | Hnrnpc | ||
| Tubb1b | Actb | Myh9 | Hspa8 | Vcp | Hspa5 | ||
| Gapdh | Hsp90aa1 | Vdac1 | Hnrnpab | Psmc4 | Tuba1c | ||
| Etfa | Ncl | Atp5a1 | Eef1a1 | Nme1 | Hspa8 | ||
| Hspa9 | Aprt | Hspd1 | Tcp1 | Actb | |||
| Actb | Nme2 | Hsp90aa1 | Hsp90aa1 | ||||
| Hsp90aa1 | Vcp | Ncl | Ncl | ||||
| Sfrs1 | Psmc4 | Aprt | Sfrs3 | ||||
| Vdac1 | Nme1 | Ube2n | Aprt | ||||
| Pkm2 | Psmc2 | Nme2 | Vdac1 | ||||
| Atp5a1 | Cct5 | Pkm2 | |||||
| Ruvbl1 | Nme1 | Pebp1 | |||||
| Hspd1 | Pkm2 | Atp5a1 | |||||
| Atp5a1 | Ruvbl1 | ||||||
| Ruvbl1 | Hspd1 | ||||||
| Hspd1 | |||||||
| GTP binding | 8 | Fkbp4 | Nme1 | Tubb2a | Eef1a1 | Nme1 | Fkbp4 |
| Tubb5 | Nme1 | Tubb5 | |||||
| Tuba1b | Tuba1c | Tuba1c | |||||
| ATPase activity | 8 | Atp5a1 | Vcp | Atp5a1 | Atp5a1 | Vcp | Atp5a1 |
| Psmc4 | Myh9 | Hspa8 | Psmc4 | Atp5h | |||
| Atp5b | Myh9 | Hspa8 | |||||
| Psmc2 | |||||||
| Enzyme binding | 8 | Actb | Actb | Actb | Gnb2l1 | Vim | Actb |
| Npm1 | Gnb2l1 | Hspd1 | Pebp1 | ||||
| Hspd1 | Hspa9 | Hspd1 | |||||
| Cotl1 | Cotl1 | ||||||
| Hspa9 | |||||||
| Cofactor binding | 5 | Gapdh | Etfa | Shmt1 | Ldhb | ||
| Etfa | Shmt1 | ||||||
| Peptidase activity | 6 | Ctsd | Uchl1 | Ctsd | Psmb4 | Psmb4 | |
| Eno1 | Eno1 | Acy1 | Uqcrc1 | ||||
| Uchl1 | Acy1 | ||||||
| Eno1 | Eno1 | ||||||
| Metal ion binding | 13 | Trim28 | Atp5b | Acy1 | Pdia6 | Acy1 | |
| Sfrs1 | Pdia6 | Nme2 | Nme2 | Uqcrc1 | |||
| Pkm2 | Nme2 | Nme1 | Nme1 | Trim28 Pkm2 | |||
| Glo1 | Nme1 | Pkm2 | Glo1 | ||||
| Eno1 | Eno1 | Impdh2 | Impdh2 | ||||
| Eno1 | Eno1 |
Ciclopirox olamine (CPX) > Retinoic acid (RA): Proteins which were more than 2-fold higher expressed in CPX-treated cells compared to RA-treated cells; CPX < RA: Proteins which were more than 2-fold higher expressed in RA-treated cells compared to CPX-treated cells; CPX > c: Proteins which were more than 2-fold higher expressed in CPX-treated cells compared to control; CPX < c: Proteins which were more than 2-fold higher expressed in control compared to CPX-treated cells; RA > c: Proteins which were more than 2-fold higher expressed in RA-treated cells compared to control; RA < c: Proteins which were more than 2-fold higher expressed in control compared to RA-treated cells.