Fig 3.

Radiographs of the proband in Family 2 (individual III-1) at age 9 years and 10 months of age showing (A) hand, (B) knee, (C) spine, and (D) hips. The radiographs were consistent with a diagnosis of MED, characterized by delayed and abnormal endochondral ossification. The hand showed marked carpal ossification delay with irregular carpal bones with a coarse internal structure. The distal epiphysis of the radius was also irregular and small. The knees had small and irregular femoral and tibial epiphyses and irregular metaphyses. The pelvis showed some flattening of the proximal femoral epiphyses but they were relatively spared. There was some irregularity of the vertebral end plates (arrow).