Table 2.
Risk of fracture in incident MG patients by type of fracture, gender and age compared to patients without MG
| Number of fractures | Rate/1,000 person-years | Age–sex adjusted HR (95 % CI) | Fully adjusted HR (95 % CI)a | |
|---|---|---|---|---|
| No MG | 426 | 12.6 | 1.00 | 1.00 |
| MG (any fracture) | 75 | 14.2 | 1.19 (0.93–1.52) | 1.11 (0.84–1.47) |
| Fracture at osteoporotic sites | 43 | 8.2 | 1.13 (0.82–1.56) | 0.98 (0.67–1.41) |
| Hip fracture | 8 | 1.5 | 0.85 (0.41–1.77) | 0.61 (0.26–1.45)b |
| Vertebral fracture | 9 | 1.7 | 2.85 (1.31–6.18) | 2.13 (0.82–5.51)c |
| Radius/ulna fracture | 11 | 2.1 | 0.92 (0.49–1.73) | 1.02 (0.51–2.04)d |
| Other fracture | 15 | 2.8 | 1.00 (0.58–1.71) | 0.86 (0.47–1.59)e |
| Fracture at non-osteoporotic sites | 32 | 6.1 | 1.29 (0.89–1.89) | 1.42 (0.93–2.17)f |
| By genderg | ||||
| Male | 27 | 10.5 | 1.11 (0.74–1.67) | 0.86 (0.52–1.42) |
| Female | 48 | 18.6 | 1.24 (0.91–1.68) | 1.20 (0.86–1.69) |
| By age at MG diagnosish | ||||
| 18–39 | 10 | 12.4 | 1.83 (0.90–3.69) | 1.76 (0.80–3.86) |
| 40–59 | 10 | 6.5 | 0.68 (0.36–1.31) | 0.62 (0.29–1.29) |
| 60–69 | 18 | 14.5 | 1.36 (0.82–2.25) | 1.42 (0.80–2.52) |
| 70–79 | 25 | 19.5 | 1.29 (0.84–4.34) | 1.18 (0.72–1.92) |
| > = 80 | 12 | 30.4 | 1.11 (0.60–2.05) | 0.97 (0.47–2.00) |
aAdjusted for age, gender, use of immunosuppressants, oral glucocorticoids and antidepressants in the previous 6 months, history of smoking and alcohol use
bAdditionally adjusted for anxiolytics and antipsychotics in the previous 6 months, history of asthma and cerebrovascular disease
cAdditionally adjusted for use of anxiolytics, NSAIDs, anti-parkinson medication in the previous 6 months, history of COPD, rheumatoid arthritis, asthma, secondary osteoporosis and BMI status but not for history of smoking
dNot adjusted for history of smoking
eNot adjusted for use of antidepressants in the previous 6 months and not for history of smoking
fAdditionally adjusted for history of stroke in the previous year and history of hypothyroidism and secondary osteoporosis. Not adjusted for antidepressant use and not for history of alcohol use
gMale MG patients are compared with male controls and female MG patients with female controls
hMG patients in each age group are only compared with control patients in the same age group