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. 2012 Oct 9;120(23):4560–4570. doi: 10.1182/blood-2012-04-421420

Figure 5.

Figure 5

Dwell times of Tconvs versus Tregs with DCs in the presence of blocking anti–CTLA-4 Fab. CD4+CD25+ and CD4+CD25− T cells from DO11.10 x Ctla4+/+ mice were incubated with anti–CTLA-4 Fab, or isotype anti–hamster IgG control. After 30 minutes, contact times were measured between DCs and T cells in the absence (DC) and presence of OVA peptide (DC-OVA). Differences between the mean values were tested using 2-tailed Student t test (GraphPad Prism 5.0). P < .05 was considered significant. Data are representative of 3 separate experiments.