Table 2.
Neuroblastoma-related miRNAs
| miRNA | Chr | Status in NB cells | Biological effect in NB cells | Validated targets in NB Cells | References |
|---|---|---|---|---|---|
| miR-34a | 1p36.22 | Deleted in 1pLOH tumors | Ectopic over-expression is pro-apoptotic Inhibits tumor growth in mouse model | E2F3, MYCN, BCL2 | [112, 113, 123, 124] |
| miR-184 | 15q25.1 | Down-regulated in MNA tumors | Ectopic over-expression is pro-apoptotic | AKT2 | [210] |
| miR-125a, miR-125b | 19q13.41, 11q24.1, 21q21.1 | Up-regulated upon ATRA treatment | Ectopic over-expression is anti-proliferative and pro-differentiation | TRKC, AP1M1, STK11IP, PSMD8, ITCH, TBC1D1, TDG, MKNK2, DGAT1, GAB2, SGPL1, LIN28B, p53 | [93, 117, 118, 211] |
| miR-128 | 2q21.3, 3p22.3 | Up-regulated upon ATRA treatment | Ectopic over-expression decreases cell motility and invasiveness | RELN, DCX | [158, 212] |
| miR-149* | 2q37.3 | Unknown | Ectopic over-expression is pro-apoptotic | AKT1, E2F1 | [213] |
| miR-214, miR-7 | 1q24.3 | Up-regulated upon ATRA treatment | Ectopic over-expression promotes neurite out growth in vitro | Unknown | [214] |
| miR-184 | 15q25.1 | Down-regulated in MNA tumors | Act as a tumor suppressor in mouse model | AKT2 | [210] |
| miR-10a, miR-10b | 17q21.32, 2q31.1 | Up-regulated upon ATRA treatment | Induce neural cell differentiation | NCOR2, SFRS1 | [119, 215] |
| miR-101 | 1p31.3, 9p24.1 | Unknown | Ectopic over-expression is anti-proliferative | MYCN | [111] |
| Let-7a | 9q22.32, 11q24.1, 22q13.31 | Down-regulated in LIN28B over-expressing tumors | Ectopic over-expression is anti-proliferative | MYCN | [93, 111] |
| Let-7e | 19q13.41 | Down-regulated in LIN28B over-expressing tumors | Ectopic over-expression is anti-proliferative | MYCN, DKK3 | [111, 216] |
| miR-124 | 8p23.1, 8q12.3, 20q13.33 | Up-regulated upon ATRA treatment | Ectopic over-expression promotes differentiation and neurite outgrowth | PTBP1, AHR | [217, 218] |
| miR-27b | 9q22.32 | Unknown | Ectopic over-expression is anti-proliferative and inhibits tumor growth in mouse model | PPARγ | [219] |
| miR-29a | 7q32.3 | Down-regulated in MNA tumors | Under-expression in tumors facilitates immune escape | B7H3 | [16, 220] |
| miR-542-5p | Xq26.3 | Down-regulated in MNA tumors | Over-expression reduces cell invasiveness in vitro and restricts tumor growth in mouse model | Unknown | [14] |
| miR-335 | 7q32.2 | MYCN repressed | Suppresses cell invasiveness | ROCK1, MAPK1, LRG1 | [15] |
| miR-204 | 9q21.12 | Down-regulated in MNA tumors | Ectopic over-expression increases sensitivity to cisplastin | BCL2, NTRK2 | [16] |
| miR-9 | 1q22, 5q14.3, 15q26.1 | MYC/MYCN activated | Ectopic over-expression is anti-proliferative, induces differentiation and inhibits migration, invasion, and angiogenesis | TRKC, ID, (MMP)-14 | [117, 221, 222] |
| miR-103 | 5q34, 20p13 | Up-regulated upon ATRA treatment | Ectopic over-expression is anti-proliferative, induces differentiation and reduces cell migration | ID2, CDK5R1 | [117, 221, 223] |
| miR-107 | 10q23.31 | Unknown | Ectopic over-expression reduces cell migration | CDK5R1 | [223] |
| miR-885 | 3p25.3 | Down-regulated on 3pLOH tumors | Ectopic over-expression inhibits cell cycle progression and cell survival | CDK2, MCM5 | [224] |
| miR-17-92 cluster | 13q31.3 | MYCN-induced cluster | pSMAD2, DKK3 | [109] | |
| miR-17-5p | 13q31.3 | Knock-down is anti-proliferative and pro-apoptotic | P21, BIM | [108] | |
| miR-17-5p, miR-20a | 13q31.3 | Endogenous down-regulation in response to ATRA | BCL2, MEF2D, MAP3K12 | [225] | |
| miR-18a, miR-19a | 13q31.3 | Endogenous knock-down impedes cell proliferation and promotes differentiation | ESR1 | [226] | |
| miR-92 | 13q31.3 | Inhibits tumor suppressor in mouse model | Unknown | [227] | |
| miR-92a, miR-19b | 13q31.3 | Unknown | DKK3 | [110] | |
| miR-340 | 5q35.3 | Inactivated by DNA methylation | Ectopic over-expression is anti-proliferative and pro-apoptotic | SOX2 | [17] |
| miR-380-5p | 14q32 | Over-expressed in MNA tumors | Knock-down induces apoptosis Systematic delivery of anti-miR-380-5p decreases tumor growth in mouse model | p53 | [18] |
| miR-7 | 9q21.32 | Down-regulated upon ATRA treatment | Endogenous knock-down promotes neurite out growth in vitro | Unknown | [9] |
| miR-210 | 11p15.5 | Unknown | Ectopic over-expression is pro-apoptotic | BCL2 | [19] |
| mir-21 | 17q23.1 | Up-regulated in MNA tumors | Ectopic over-expression increases resistance to cisplastin and cell proliferation | Unknown | [20] |
| miR-152 | 17q21.32 | Up-regulated upon ATRA treatment | Ectopic over-expression reduced cell invasiveness and anchorage independent growth | DNMT1 | [158] |