Table 3.
Summary of nonhematologic and hematologic toxicity (cycle 1) presenting in two or more patients
| Toxicity | Patients | Toxicity events by dose level (UCN-01/irinotecan) |
|||||||
|---|---|---|---|---|---|---|---|---|---|
| 50/60 (n = 1) |
70/60 (n = 6) |
90/60 (n = 4) |
70/90 (n = 5) |
||||||
| 1–2 | 3–4 | 1–2 | 3–4 | 1–2 | 3–4 | 1–2 | 3–4 | ||
| Nonhematologic | |||||||||
| Diarrhea | 11 | 1 | 3 | 1 | 3 | 2 | 1 | ||
| Fatigue | 10 | 5 | 2 | 3 | |||||
| Nausea | 10 | 2 | 1 | 2 | 1 | 4 | |||
| Vomiting | 9 | 2 | 1 | 2 | 1 | 3 | |||
| Anorexia | 8 | 4 | 1 | 3 | |||||
| Headache | 6 | 1 | 2 | 3 | |||||
| Hypotension | 6 | 1 | 1 | 4 | |||||
| Diaphoresis | 6 | 2 | 2 | 2 | |||||
| Hyperglycemia | 5 | 1 | 1 | 2 | 1 | ||||
| Cramping | 5 | 3 | 1 | 1 | |||||
| Hypophosphatemia | 4 | 2 | 2 | ||||||
| Lightheadedness | 3 | 1 | 1 | 1 | |||||
| Fever | 3 | 2 | 1 | ||||||
| Elevated ALT | 3 | 3 | |||||||
| Hematologic | |||||||||
| Anemia | 3 | 1 | 2 | ||||||
| Lymphopenia | 2 | 2 | |||||||
| Leukopenia | 2 | 2 | |||||||
| Febrile neutropenia | 1 | 1 | |||||||