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Dose escalation scheme and DLTs
| Dose level | Duration of infusion (h) | Infusion rate (mg/m2/day) | Total dose (mg/m2) | No. of patients | No. of cycles | No. of DLTs |
|---|---|---|---|---|---|---|
| 1 | 48 | 3 | 6 | 4 | 7 | 0 |
| 2A | 72 | 3 | 9 | 5 | 9 | 2 |
| 2B | 72 | 2 | 6 | 3 | 6 | 0 |
| 3A | 96 | 2.25 | 9 | 5 | 12 | 2 |
| 3B (MTD) | 96 | 1.88 | 7.5 | 4 | 14 | 0 |
DLT, dose-limiting toxicity; MTD, maximum tolerated dose.
