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Summary of grade 3 and 4 hematological toxic effects
| Toxicity | Patients | Toxicity events by dose level |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 (n = 4) |
2A (n = 5) |
2B (n = 3) |
3A (n = 5) |
3B (n = 4) |
|||||||
| Hematological | 3 | 4 | 3 | 4 | 3 | 4 | 3 | 4 | 3 | 4 | |
| Neutropenia | 14 | 2 | 3 | 2 | 4 | 2 | 1 | ||||
| Leukopenia | 5 | 1 | 1 | 1 | 1 | 1 | |||||
| Thrombocytopenia | 3 | 2 | 1 | ||||||||
| Anemia | 3 | 1 | 1 | 1 | |||||||
| Neutropenic fever | 1 | 1 | |||||||||
