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Summary of grade 3 and 4 non-hematological toxic effects
| Toxicity | Patients | Toxicity events by dose level |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 (n = 4) |
2A (n = 5) |
2B (n = 3) |
3A (n = 5) |
3B (n = 4) |
|||||||
| Non-hematological | 3 | 4 | 3 | 4 | 3 | 4 | 3 | 4 | 3 | 4 | |
| Rash | 2 | 1 | 1 | ||||||||
| Nausea | 1 | 1 | |||||||||
| Hand–foot syndrome | 1 | 1 | |||||||||
| Hyperbilirubinemia | 1 | 1 | |||||||||
| Neuropathy | 1 | 1 | |||||||||
| Pruritus | 1 | 1 | |||||||||
| Elevated LFT | 1 | 1 | |||||||||
| Erythema | 1 | 1 | |||||||||
| Hypocalcemia | 1 | 1 | |||||||||
LFT, liver function tests
