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Summary of pharmacokinetics parameters of troxacitabine
| Parameter | 3 mg/m2/day 48 h n = 4 |
3 mg/m2/day 72 h n = 5 |
2 mg/m2/day 72 h n = 3 |
2.25 mg/m2/day 96 h n = 5 |
1.88 mg/m2/day 96 h n = 2 |
|---|---|---|---|---|---|
| Css (ng/ml) | 22.9 ± 1.99 | 31.6 ± 7.60 | 21.1 ± 3.26 | 23.7 ± 8.67 | 24.5 ± 5.4 |
| CL (ml/min/m2) | 91.6 ± 8.1 | 68.9 ± 15.4 | 67.0 ± 10.5 | 71.9 ± 21.4 | 54.3 ± 11.3 |
Values are reported as the mean ± standard deviation.
Css, steady-state plasma concentration; CL, clearance.
