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. 2012 Jul 13;445(Pt 3):377–382. doi: 10.1042/BJ20120820

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© 2012 The Author(s) The author(s) has paid for this article to be freely available under the terms of the Creative Commons Attribution Non-Commercial Licence (http://creativecommons.org/licenses/by-nc/2.5/) which permits unrestricted non-commercial use, distribution and reproduction in any medium, provided the original work is properly cited.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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The rapid down-regulation of CYP2B proteins elicited by IL-1 requires the induction of NOS2, and subsequent NO production. We hypothesized previously that NO modifies the CYP2B protein (CYP2B*) and tags it for ubiquitination (CYP2B-Ub) and for proteasomal degradation [26]. IL-1 acts via NO-independent mechanisms to accelerate this degradation, including the induction of the immunoproteasome.