Figure 2. Hsp90α knockdown reduces hERG trafficking.
A) Control, Hsp90α, and Hsp90β targeted siRNA were transfected into hERG-HEK cells. The effect of siRNA was analyzed by Western Blot Analysis 48 h. post transfection. Actin represents a loading control. B) Equation for trafficking efficiency. C) Densitometry analysis of Western Blots from A (N=3); *, p < 0.02; **, p < 0.01 versus control siRNA values.