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Steps leading to the putative Mode 1 to Mode 2 rearrangement. In Mode 1, the N-terminal tail of one UmuD (green) can potentially bind to the backside of RecA1 (yellow) and inhibit the RecA1 rearrangement, until UmuD is proteolyzed to UmuD′, which yields a shorter N-terminal tail that can no longer interact with RecA1 (see text) and might allow rearrangement to Mode 2.
