Table 3.
Magnetic Resonance Imaging Callosal Volumes (mm3) Among Childhood-Onset Schizophrenia Probands (COS), Healthy Comparison Subjects (NV), and Healthy Siblings (SIB)
| Adjusted (for ICV) Volume at the average age | Unadjusted (for ICV) Volume at the average age | |||||
|---|---|---|---|---|---|---|
| COS Mean (SE) | NV Mean (SE) | SIB Mean (SE) | COS Mean (SE) | NV Mean (SE) | SIB Mean (SE) | |
| CC Posterior | 268.47 (60.02) | 269.21 (60.90) | 244.98 (62.26) | 867.36 (15.94) | 880.25 (15.79) | 858.71 (20.14) |
| CC Mid-Posterior | 76.16 (59.79) | 95.90 (60.89) | 107.42 (61.78) | 417.58 (11.12) | 443.77 (11.16) | 456.74 (14.46) |
| CC Central | 112.34 (66.04) | 148.87 (67.05) | 131.11(68.08) | 467.54 (12.38) | 509.93 (12.41) | 496 (16.14) |
| CC Mid-Anterior | 98.22 (50.64) | 107.79 (50.86) | 100.75 (51.92) | 465.34 (11.42) | 478.02 (11.38) | 471.34 (14.55) |
| CC Anterior | 195.76 (64.25) | 175.86 (65.21) | 174.3 (66.56) | 867.26 (15.89) | 858.12 (15.71) | 859.26 (19.97) |
| CC Total | 618.57 (212.72) | 653.13 (215.86) | 612.47 (220.31) | 3092.18 (52.65) | 3173.29 (52.23) | 3140.62 (66.81) |
COS= Childhood-Onset Schizophrenia probands; NV= healthy comparison subjects; SIB= healthy siblings of Childhood-Onset Schizophrenia probands Data were covaried for gender at the mean centered age (17.31 years [SD=4.66]). Adjusted values were covaried for intracranial volume.