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Schematic representation of the crosstalk between ERK and p38 MAPKs in homocysteine-NMDAR induced neuronal cell death. (A) Homocysteine-NMDAR stimulation leads to sustained two-tier activation of ERK MAPK and biphasic activation of p38 MAPK where p38 MAPK activation is downstream and dependent on ERK MAPK. (B) Glutamate-NMDAR stimulation leads to transient activation of ERK and p38 MAPKs that are independent of each other.
