Table 1 (a).
Concentrations and AUCs of kb-NB142-70 in plasma and tissues after administration of 25 mg/kg kb-NB142-70 iv to C.B-17 SCID female mice bearing PC-3 xenografts
| Time (Min) |
Plasma (nmol/mL) |
Tumor (nmol/g) |
Liver (nmol/g) |
Kidney (nmol/g) |
Lung (nmol/g) |
Spleen (nmol/g) |
Heart (nmol/g) |
Brain (nmol/g) |
Skeletal Muscle (nmol/g) |
RBC (nmol/mL) |
Fat (nmol/g) |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 5 | 36.9±8.3 | 5.62±1.63 | 23.4±1.1 | 63.4±13.7 | 26.8±3.3 | 21.2±3.8 | 14.5±2.0 | 6.34±1.72 | 18.4±4.6 | 23.6±1.7 | 9.92±0.52 |
| 10 | 23.4±7.4 | 11.8±4.0 | 6.41±0.56 | 48.9±15.8 | 16.7±1.2 | 12.6±2.5 | 13.1±2.5 | 5.07±0.57 | 15.5±4.0 | 13.2±2.7 | 8.93±1.71 |
| 15 | 10.3±3.7 | 5.22±3.60 | 8.41±0.29 | 27.0±12.4 | 10.4±4.9 | 8.03±3.39 | 6.23±1.96 | 2.40±0.40 | 9.45±2.47 | 6.94±2.26 | 6.65±0.74 |
| 30 | 2.0±1.9 | 4.22±1.92 | ND | 10.1±2.0 | 2.95±1.69 | ND | 2.60±0.53 | 0.84±0.11 | 2.28±0.56 | 2.31±1.70 | 2.80±0.45 |
| 60 | ND | 1.24±0.95 | ND | 2.87±0.56 | ND | ND | ND | ND | 1.05±0.02 | ND | 2.62±1.35 |
| 120 | ND | 0.79±0.32 | ND | 3.76±0.82 | ND | ND | ND | ND | 0.95±0.01 | ND | 0.77±0.13 |
| 240 | ND | 0.57±0.60 | ND | 1.78±0.29 | ND | ND | ND | ND | 1.00±0.01 | ND | 0.45±0.06 |
| 360 | ND | 1.21±0.78 | ND | ND | ND | ND | ND | ND | 0.97±0.06 | ND | 0.36±0.03 |
| 960 | ND | ND | ND | ND | ND | ND | ND | ND | ND | ND | 0.85±0.42 |
| 1440 | ND | ND | ND | ND | ND | ND | ND | ND | ND | 0.44±0.07 | |
| AUC0→∞ (nmol·min/mL) or (nmol·min/g) |
409 | 731 | 266 | 1712 | 377 | 288 | 236 | 85 | 748 | 288 | 1681 |