Table 3.
Human residence times (in Bq-hr/Bq administered) estimates of [18F]Nifene based on mouse residence times and modeled organ mass differences between the two species.
| Source Organ | Male average (± SD) | Female average (± SD) |
|---|---|---|
| Brain | 3.58E-02 ± 5.11E-03 | 3.30E-02 ± 2.03E-03 |
| LLI Content* | 2.98E-03 ± 1.19E-03 | 4.24E-03 ± 1.27E-03 |
| SI Content* | 4.01E-03 ± 1.59E-03 | 6.00E-03 ± 9.80E-04 |
| Stomach Content | 2.03E-02 ± 1.13E-02 | 1.83E-02 ± 5.13E-03 |
| Heart Content | 5.32E-03 ± 7.57E-04 | 4.19E-03 ± 3.23E-04 |
| Kidneys | 4.05E-02 ± 2.03E-02 | 2.49E-02 ± 4.38E-03 |
| Liver | 6.96E-02 ± 1.84E-02 | 5.59E-02 ± 3.99E-03 |
| Lungs | 2.02E-02 ± 6.19E-04 | 1.34E-02 ± 1.45E-03 |
| Pancreas | 4.48E-03 ± 2.07E-03 | 4.50E-03 ± 1.27E-03 |
| Cortical Bone | 3.28E-02 ± 1.07E-02 | 2.91E-02 ± 8.41E-03 |
| Spleen | 9.88E-03 ± 2.85E-03 | 7.78E-03 ± 1.77E-03 |
| Testes | 1.21E-03 ± 8.44E-04 | N/A |
| Thymus | 3.89E-04 ± 8.77E-05 | 4.47E-04 ± 4.27E-05 |
| UB Content* | 9.67E-02 ± 3.97E-02 | 1.27E-01 ± 4.13E-02 |
| Uterus | N/A | 4.68E-03 ± 1.67E-03 |
| Remainder Body | 2.12E+00 ± 1.63E-01 | 1.62E+00 ± 1.82E-01 |
LLI = lower large intestine, SI = small intestine, UB = urinary bladder