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Age-, training-, and treatment-associated differences in pCREB and CREB immunoreactivity in area CA3 of the hippocampus. (A) Representative photomicrographs of pCREB immunostaining. Scale bar = 100 microns. (B) There were no significant age-, training-, or treatment-related differences in pCREB levels. (C) There were significantly lower CREB levels in old compared to young rats. (D) pCREB:CREB ratios were significantly elevated in old compared to young rats.
