Figure 5.
Age-, training-, and treatment-associated differences in pCREB and CREB immunoreactivity in the basolateral nucleus of the amygdala. (A) Representative photomicrographs of pCREB immunostaining. (B) Old rats had training-related deficits in pCREB activation, which were attenuated by epinephrine. (**) ps < .01 vs. young untrained group. (+) p < .05 vs. old untrained group. Scale bar = 50 microns. (C) There were significantly lower CREB levels in old compared to young rats. (D) Old rats had training-related deficits in pCREB:CREB ratios, which were attenuated by epinephrine. (**) ps < .01 vs. young untrained group. (+) p < .05 vs. old untrained group.