Table 5.
Summary of functional magnetic resonance imaging studies (conducted between 2001 and 2012) on effects of obesity on brain function included in Figs 4 and 6. Studies are grouped by stimulation paradigm into two major categories. Number of obese (S) and control (C) subjects and tasks are provided in addition to main results.
| Subjects | Task | Results | |
|---|---|---|---|
| Cue reactivity | |||
| Rothemund et. al; 2007 | 13S & 13C | High/low calorie visual cues | striatum, HIPP, INS↑ (high calorie) |
| Stoeckel et. at; 2008 | 12S & 12C | High/low calorie visual cues | OFC, AMY, Nacc, VPFC, INS, ACC, GP, striatum, HIPP↑ |
| Wallner-Liebmann et al; 2010 | 12S & 12C | High/low calorie visual cues | Insulin plasma level was correlated with HIPP activation |
| Dimitropoulos et. al; 2012 | 22S & 16C | High/low calorie visual cues | temporal and limbic ↑ after eating |
| Other (Intake, reward, gastric distention) | |||
| Stice et. al; 2008 | 76S | Food intake & TaqIA A1 gene | TaqIA: no A1 > A1: BMI correlate with striatal activation |
| Tomasi et. al; 2009b | 24S | Gastric distention | Cerebellum and insula↑; midbrain, hypothalamus, amygdala↓ |
| Stice et. al; 2011 | 35S & 25C | Reward | Adolecents with high risk for obesity: caudate↑ |
Arrows indicate activation increases (↑) or decreases (↓).