Table 2.
Risk of Hodgkin Lymphoma Associated with Body Size, Stratified by Gender and Age, in Massachusetts and State of Connecticut, 1997–2000a
| Variables | Men |
Women |
P-value for heterogeneity by gender | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| < 35 years (147/163)b |
≥ 35 years (134/197)b |
< 35 years (119/145)b |
≥ 35 years (130/160)b |
||||||||||
| Ca/Co | OR | 95%CI | Ca/Co | OR | 95%CI | Ca/Co | OR | 95%CI | Ca/Co | OR | 95%CI | ||
| Weightc, kg | |||||||||||||
| Q1 | 32/37 | 1.0 | 31/44 | 1.0 | 10/25 | 1.0 | 50/40 | 1.0 | 0.05 | ||||
| Q2 | 40/44 | 1.1 | 0.5,2.1 | 40/59 | 1.0 | 0.5,1.9 | 39/48 | 2.1 | 0.9,5.1 | 42/38 | 0.9 | 0.5,1.7 | |
| Q3 | 26/41 | 0.7 | 0.4,1.5 | 25/43 | 0.8 | 0.4,1.7 | 34/36 | 2.6 | 1.1,6.5 | 22/42 | 0.4 | 0.2,0.8 | |
| Q4 | 49/41 | 1.3 | 0.7,2.5 | 38/51 | 1.1 | 0.6,2.1 | 36/36 | 3.0 | 1.2,7.6 | 16/40 | 0.3 | 0.2,0.7 | |
| P for trend | 0.6 | 0.9 | <0.01 | <0.01 | |||||||||
| P for heterogeneity by age | 0.08 | 0.06 | |||||||||||
| Heightd, cm | |||||||||||||
| Q1 | 35/42 | 1.0 | 26/39 | 1.0 | 17/41 | 1.0 | 33/36 | 1.0 | 0.45 | ||||
| Q2 | 41/47 | 1.0 | 0.6,2.0 | 34/50 | 1.1 | 0.6,2.2 | 41/30 | 3.3 | 1.6,7.1 | 37/40 | 0.9 | 0.4,1.7 | |
| Q3 | 37/36 | 1.1 | 0.6,2.2 | 33/52 | 1.1 | 0.5,2.1 | 35/40 | 2.2 | 1.0,4.6 | 29/42 | 0.7 | 0.3,1.4 | |
| Q4 | 34/38 | 1.0 | 0.5,2.0 | 41/56 | 1.2 | 0.6,2.3 | 26/34 | 1.9 | 0.9,4.1 | 31/42 | 0.7 | 0.3,1.4 | |
| P for trend | 0.9 | 0.7 | 0.3 | 0.2 | |||||||||
| P for heterogeneity by age | 0.20 | 0.68 | |||||||||||
| BMIe, kg/m2 | |||||||||||||
| Q1 | 43/40 | 1.0 | 35/49 | 1.0 | 24/36 | 1.0 | 45/40 | 1.0 | <.0001 | ||||
| Q2 | 29/42 | 0.7 | 0.4,1.3 | 33/49 | 1.0 | 0.5,1.9 | 21/37 | 0.8 | 0.4,1.8 | 42/40 | 0.9 | 0.5,1.7 | |
| Q3 | 24/40 | 0.5 | 0.3,1.0 | 30/49 | 0.8 | 0.4,1.6 | 37/36 | 1.6 | 0.8,3.2 | 27/40 | 0.6 | 0.3,1.2 | |
| Q4 | 51/41 | 1.1 | 0.6,2.0 | 36/50 | 1.0 | 0.6,2.0 | 37/36 | 1.8 | 0.9,3.8 | 16/40 | 0.4 | 0.2,0.8 | |
| P for trend | 0.9 | 1.0 | <0.01 | <0.01 | |||||||||
| P for heterogeneity by age | 0.25 | 0.01 | |||||||||||
| BMI, kg/m2 | |||||||||||||
| Normal, 18.5 to <25 | 70/77 | 1.0 | 42/52 | 1.0 | 74/99 | 1.0 | 77/69 | 1.0 | 0.01 | ||||
| Overweight, 25 to <30 | 52/68 | 0.8 | 0.5,1.3 | 62/104 | 0.7 | 0.4,1.3 | 31/22 | 2.1 | 1.1,4.0 | 32/44 | 0.6 | 0.4,1.2 | |
| Obese, >=30 | 25/18 | 1.4 | 0.7,3.0 | 30/41 | 0.9 | 0.5,1.8 | 14/24 | 0.9 | 0.4,1.9 | 21/47 | 0.4 | 0.2,0.8 | |
| P for trend | 0.7 | 0.9 | 0.6 | <0.01 | |||||||||
| P for heterogeneity by age | 0.51 | 0.01 | |||||||||||
Abbreviations: BMI, body mass index; ca/co; numbers of cases and controls; CI, confidence interval; OR, odds ratio; Q, quartile.
Adjusted for age (with indicator variables for 5-year intervals), gender (male, female), state of residence (Connecticut, Massachusetts), race (white, nonwhite), education (less than high school, high school, college, advanced degree), and smoking history (ever, never).
The number of cases/the number of controls.
Weight quartiles based on distributions of the control group in total subjects: Q1 (< 65.9), Q2 (65.9 to < 77.3), Q3 (77.3 to < 88.6), Q4 (≥ 88.6); in male and young adults: Q1 (< 72.7), Q2 (72.7 to < 80.9), Q3 (80.9 to < 90.9), Q4 (≥ 90.9); in male and older adults: Q1 (< 75.0), Q2 (75.0 to < 84.1), Q3 (84.1 to < 94.5), Q4 (≥ 94.5); in female and young adults: Q1 (< 54.5), Q2 (54.5 to < 61.4), Q3 (61.4 to < 71.4), Q4 (≥ 71.4); in female and older adults: Q1 (< 59.5), Q2 (59.5 to < 72.7), Q3 (72.7 to < 85.2), Q4 (≥ 85.2).
Height quartiles based on distributions of the control group in total subjects: Q1 (< 165.1), Q2 (165.1 to < 172.7), Q3 (172.7 to < 177.8), Q4 (≥ 177.8); in male and young adults: Q1 (< 172.7), Q2 (172.7 to < 177.8), Q3 (177.8 to < 182.9), Q4 (≥ 182.9); in male and older adults: Q1 (< 172.7), Q2 (172.7 to < 177.8), Q3 (177.8 to < 182.9), Q4 (≥ 182.9); in female and young adults: Q1 (< 157.5), Q2 (157.5 to < 165.1), Q3 (165.1 to < 167.6), Q4 (≥ 167.6); in female and older adults: Q1 (< 160.0), Q2 (160.0 to < 165.1), Q3 (165.1 to < 170.2), Q4 (≥ 170.2).
BMI quartiles based on distributions of the control group in total subjects: Q1 (< 22.8), Q2 (22.8 to < 25.5), Q3 (25.5 to < 28.9), Q4 (≥ 28.9); in male and young adults: Q1 (< 23.6), Q2 (23.6 to < 25.1), Q3 (25.1 to < 27.4), Q4 (≥ 27.4); in male and older adults: Q1 (< 24.5), Q2 (24.5 to < 26.7), Q3 (26.7 to < 30.0), Q4 (≥ 30.0); in female and young adults: Q1 (< 21.2), Q2 (21.2 to < 22.7), Q3 (22.7 to < 26.6), Q4 (≥ 71.4); in female and older adults: Q1 (< 22.5), Q2 (22.5 to < 26.1), Q3 (26.1 to < 30.7), Q4 (≥ 30.7).