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. Author manuscript; available in PMC: 2014 Feb 15.
Published in final edited form as: Bioorg Med Chem Lett. 2012 Dec 27;23(4):1004–1007. doi: 10.1016/j.bmcl.2012.12.037

Table 2. SAR of heterotricyclic anilide phthalazinone inhibitors.

Assays as described in 10.

graphic file with name nihms431760u2.jpg
Compound R (−)-BSA (nM) (+)-BSA (nM)
50 graphic file with name nihms431760t1.jpg 93 ± 15 85 ± 12
51 graphic file with name nihms431760t2.jpg >5000 ND
52 graphic file with name nihms431760t3.jpg 64 ± 11 72 ± 15
53 graphic file with name nihms431760t4.jpg 20 ± 5 150 ± 20
54 graphic file with name nihms431760t5.jpg 4 ± 1 30 ± 10
55 graphic file with name nihms431760t6.jpg >5000 ND
56 graphic file with name nihms431760t7.jpg >5000 ND
57 graphic file with name nihms431760t8.jpg >5000 ND

All values are average of three independent determinations unless otherwise stated. ND, not determined.