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. Author manuscript; available in PMC: 2014 Mar 1.
Published in final edited form as: Biochim Biophys Acta. 2012 Dec 20;1832(3):391–399. doi: 10.1016/j.bbadis.2012.12.005

Figure 2. IGF-1 upregulates glutathione peroxidase activity in a dose-dependent and time-dependent manner.

Figure 2

In hAECs (A) Superoxide dismutase and (B) catalase activity were determined after 24 hr exposure to IGF-1. There was no statistically significant alteration in enzyme activities. (C) Glutathione peroxidase activity was determined after 2 hr, 6hr, and 24 hr of exposure to IGF-1 (0 ng/mL; closed square, 50 ng/mL; open circle, 100 ng/mL; closed circle). *P<0.01 vs. 0 ng/mL IGF-1, n=4. #P<0.01 vs. 50 ng/mL IGF-1, n=4. (D) Total glutathione (GSH) levels were determined after 24 hr exposure to IGF-1.