Figure 5.
Recombinant PKL-FLAG binds to free DNA and mononucleosomes. (A) Recombinant PKL (44–275 ng) was incubated with 10 ng of 277-bp DNA end-labeled with Alex Fluor 647 and the mixture was analyzed by electrophoresis on a 2% agarose gel. (B) Recombinant PKL (44–275 ng) was incubated with 20 ng of mononucleosomes containing the same end-labeled 277-bp DNA fragment as in panel A and then analyzed by electrophoresis on a 4% PAGE gel.