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. Author manuscript; available in PMC: 2014 Apr 1.
Published in final edited form as: Biopolymers. 2013 Apr;99(4):225–232. doi: 10.1002/bip.22157

Figure 2. Effects of histone modifications on compactness of a constitutive heterochromatin structure.

Figure 2

(A) ChIP assay depicting the percentage of nucleosomes containing the H4Ac modification in both untreated cells (blue), cells treated with TSA (1 μM for 4 h; red) and cells that were given 5 days to recovery after removal of the TSA (green). Data show the mean ± s.e.m of three (untreated and recovery) or six (TSA) independent ChIP experiments. *P < 0.05, **P < 0.01. (B) Nuclei from 6C2 cells either untreated or treated with TSA (for 16 h) were digested with MspI, floated out of the nuclei, sedimented on a sucrose gradient and analysed by quantative PCR (copied from Giles et al.56).