A. Differences in pre-mobilization marrow plasmacytosis as a function of novel induction regimen utilized. Patients were stratified by the type of novel induction agent received, either thalidomide-, lenalidomide-, bortezomib-, or combination (i.e., VTD or VRD)- based. A significant difference was observed between groups. Planned comparisons revealed that the combination induction regimens led to significantly less residual marrow plasmacytosis than lenalidomide-based induction (*).
Figure 1B. Differences in day 1 peripheral blood CD34(+) cell count as a function of novel induction regimen utilized. Patients were stratified as in Fig 1A. A significant difference was observed between groups and planned comparisons revealed that patients receiving bortezomib-based induction had higher peripheral blood CD34(+) cell counts than others (*).
Figure 1C. Differences in day 1 CD34(+) cell collection as a function of novel induction regimen utilized. Patients were stratified as in Fig 1A. A significant difference in day 1 CD34(+) cell collection was observed between groups and planned comparisons revealed that patients receiving bortezomib-based induction had higher day 1 CD34(+) cell collections than others (*).