Table 2.
Frequency of overall and severe organ involvement in African-American and Caucasian SSc patients.
| Organ System | African-American (n=203) | Caucasian (n=2945) | p-value | |||
|---|---|---|---|---|---|---|
| Overall | Severe | Overall | Severe | Overall | Severe | |
| Vascular | 201 (99%) | 97 (48%) | 2880 (98%) | 1296 (44%) | NS | NS |
| Skin | 47 (23%) | 618 (21%) | NS | |||
| Joint/tendons | 172 (85%) | 45 (22%) | 2331 (79%) | 589 (20%) | 0.06 | NS |
| Skeletal Muscle | 54 (27%) | 12 (6%) | 367 (12%) | 59 (2%) | < .0001 | 0.001 |
| *GI Tract | 70% 143/169 | 12% (20/169) | 62% (1826/2312) | 11% (254/2312) | 0.02 | NS |
| *Pulmonary Fibrosis | 54% (100/186) | 32% (60/186) | 33% (973/2562) | 13% (337/2562) | < .0001 | 0.0001 |
| *PAH | 11% (23/149) | 11% (17/148) | 11% (317/2005) | 12% (243/2005) | NS | NS |
| * Heart | 20% (43/173) | 18% (31/173) | 17% (529/2411) | 16% (382/2411) | NS | NS |
| Kidney | 25 (13%) | 20 (10%) | 282 (10%) | 236 (8%) | NS | NS |
*
proportion of patients classified as severe with denominator being total number with objective data that permits severity assessment. All others used all patients as denominator.