Table 1.
Representative studies that have measured TL using southern blot analysis of TRF from different tissues
|
Reference |
N (male/female) |
Age |
Tissue |
Study outcome |
Mean telomere lengtha in Kbp |
|---|---|---|---|---|---|
| Glass et al. (2010) [31] |
520 Control (n/a) 20 Cases (n/a) |
Adults | Leukocyte | Physical and sexual abuse |
6.97 (SD = 0.67) 7.04 (SD = 0.58) |
| Aviv et al. (2009) [75] |
450 Caucasians 185 African-Americans |
31.4 (at baseline) 31.4 (at baseline) |
Leukocyte | Age-related longitudinal analysis |
7.29 (SD = 0.73) 7.85 (SD = 0.73) |
| Cherkas et al. (2008) [103] |
2,152 Female 249 Male |
48.6 (+/−12.8) 48.3 (+/−13.7) |
Leukocyte | Physical activity in leisure time |
7.0 (SD = 0.6) |
| Damjanovic et al. (2007) [104] |
41 Controls (11/30) 41 Cases (11/30) |
65 (+/−1) | PBMC T cells Monocyte |
Immune function of Alzheimer’s caregivers |
6.2 (SE = 0.10) case 6.4 (SE = 0.10) control 6.3 (SE = 0.20) case 6.5 (SE = 0.20) control 5.7 (SE = 0.10) case 5.9 (SE = 0.10) control |
| Simon et al. (2006) [25] |
44 Controls (25/19) 44 Cases (23/21) |
50.5 (+/−8.4) 51.1 (+/−7.7) |
Leukocyte | Mood disorder | 7.64 (SD = 1.10) 6.98 (SD = 0.84) |
| Andrew et al. (2006) [105] |
2,050 Female | 47.8 (+/−12.4) range 18 to 80 |
WBC | Linkage analysis | 7.1 (SD = 0.69) range 5.1–9.4 |
| Okuda et al. (2002) [106] |
83 African-Americans (n/a) 83 African-Americans (n/a) 48 Caucasians (n/a) 43 Caucasians (n/a) 29 Hispanics (n/a) 27 Hispanics (n/a) |
Newborns | WBC Umbilical artery WBC Umbilical artery WBC Umbilical artery |
Telomere dynamics in newborns |
10.98 (SE = 0.09) 10.99 (SE = 0.08) 10.92 (SE = 0.11) 10.89 (SE = 0.09) 11.26 (SE = 0.10) 11.25 (SE = 0.12) |
| Friedrich et al. (2000) [72] |
9 Patients (n/a) Surgery for hip fractures |
73 to 95 | Leukocyte Skin Synovial |
Comparative tissue analysis |
6.54 (SD = 0.52) 7.79 (SD = 0.60) 7.91 (SD = 0.42) |
| Slagboom et al. (1994) [34] |
Young: 16 MZ, 15 DZ Adolescent: 15 MZ, 14 DZ Adult: 28 MZ, 27 DZ |
4.15 (+/−1.4) 17.1 (+/−2.4) 43.7 (+/−5.8) |
WBC | Heritability analysis | 8.3 (SD = 0.64) 7.8 (SD = 0.56) 7.3 (SD = 0.76) |