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Dose–response curves for effects of cocaine on locomotor activity of mice. Locomotor activity was determined after IP injections of various doses of cocaine to (○) control mice or (●) mice after chronic ingestion of caffeine for 4 days followd by 2 h of withdrawal. (A) Total distance traveled. (B) Percent of locomotor activity relative to mice injected with vehicle. Values are means ± SEM (n = 5–25).
