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. Author manuscript; available in PMC: 2014 Jan 9.
Published in final edited form as: Neuron. 2013 Jan 9;77(1):19–34. doi: 10.1016/j.neuron.2012.12.022

Figure 2. Different models of projection neuron cell-type specification in the developing neocortex.

Figure 2

(A) A single kind of RGC progenitor sequentially generates all subtypes of projection neurons and macroglia. The fate potential of the common RGC is progressively restricted over time; thus, projection neuron subtype identity is specified by birth date. (B) Distinct subtypes of RGC progenitors co-exist and are pre-specified to generate different subtypes of projection neurons and macroglia. Projection neuron subtype fate is therefore specified by progenitor type, rather than by birth date. VZ, ventricular zone; SVZ, subventricular zone; LL, lower layers; UL, upper layers; MZ, marginal zone.