Table 2. Substitutions in genome sequence of rabies virus BDR5 from Bangladesh compared with genome sequence of strain from India (AY956319)*.
| Protein, amino acid substitution | Site/domain/region of protein† |
|---|---|
| N | |
| Asp378 → Glu378 | Antigenic site IV |
| Gln422 → Arg422 |
– |
| P | |
| Ser64 → Pro64 | Variable domain I |
| Gln71 → Thr71 | Variable domain I |
| Asn90 → Ser90 | N protein binding site in variable domain II |
| Pro159 → Ser159 | N protein binding site in variable domain II |
| His162 → Ser162 | N protein binding site in variable domain II |
| Asn166 → Ser166 | N protein binding site in variable domain II |
| Ala174 → Val174 |
N protein binding site in variable domain II |
| M | |
| Leu21 → Pro21 | – |
| Ser46 → Gly46 | – |
| Ile168 →Val168 |
– |
| G | |
| Ala-(minus)15 → Val-15 | Signal peptide |
| Val-(minus)6 → Phe-6 | Signal peptide |
| Val7 → Ile7 | – |
| Asp146 → Asn146 | Putative additional N-glycosylation: NKS |
| Val427 → Ile427 | – |
| Arg462 → Gly462 | Transmembrane domain |
| His465 → Arg465 | Transmembrane domain |
| Gly473 → Ser473 |
Transmembrane domain |
| L | |
| Asp18 → Glu18 | – |
| Ala19 → Thr19 | – |
| Arg315 → Lys315 | Conserved domain I |
| Val361 → Leu361 | Conserved domain I |
| His640 → Gln640 | Conserved domain III |
| Lys657 → Arg657 | Conserved domain III |
| Ala966 → Thr966 | Conserved domain IV |
| Pro1133 → Ser1133 | Conserved domain V |
| Arg1307 Lys1307 | Conserved domain IV |
| Asp1373 → Gly1373 | – |
| Leu1626 → Val1626 | – |
| Leu1654 → Ser1654 | – |
| Val1755 → Ile1755 | – |
| Cys1825 → Tyr1825 | – |
| Asn1841 → Lys1841 | – |
| Gln1845 → His1845 | – |
| Cys1872 → Phe1872 | – |
| Asn2091 → Ser2091 | – |
*N, nucleoprotein; P, phosphoprotein; M, matrix protein; G, glycoprotein; L, polymerase. †– indicates that the amino acid substitution was in a location that has no site/domain/region name. NKS, asparagine-lysine-serine.