Table 5. Histopathologic and immunohistochemical findings in major systems of ferrets infected with NiV from Bangladesh or Malaysia*.
| System, predominant lesion | No. animals with lesion/antigen/vasculitis† |
|
|---|---|---|
| NiV-Bangladesh, n = 8 | NiV-Malaysia, n = 7 | |
| Respiratory | ||
| Acute rhinitis | 7/5/1 | 6/7/0 |
| Acute bronchoalveolitis |
8/8/1 |
7/7/4 |
| Lymphoid | ||
| Lymphadenitis | 8/8/1 | 7/7/0 |
| Splenic necrosis |
7/7/1 |
6/7/1 |
| Renal, glomerular necrosis |
8/6/0 |
6/7/1 |
| Hepatic, focal hepatic necrosis |
8/7/0 |
1‡/2/0 |
| Central nervous | ||
| Meningitis | 0/4/0 | 2/5/1 |
| Encephalitis | 0/7/0 | 0/3/0 |
*NiV, Nipah virus. †No. animals in which the predominant lesion was observed/antigen staining was observed in that organ or tissue/vasculitis was present in that organ or tissue. For all animals, vasculitis was associated with antigen staining in blood vessel endothelium or tunica media. ‡This animal also had cholecystitis with associated viral antigen.