Table 4. Direct Arylation of N-Substituted Benzylic Aminesa.
entry | starting material | R1 | R2 | convb (%) |
---|---|---|---|---|
1 | 1a | H | H | 9 |
2 | 4a | Me | H | 86 |
3 | 17 | H | Me | 8 |
4 | 18 | Me | Me | 17 |
Reaction conditions: Benzylic amine (0.5 mmol), 6a (0.75 mmol), Ru3(CO)12 (5 mol %), and pinacolone (0.5 mL).
Conversion determined by GC analysis with respect to benzylic amine.