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. Author manuscript; available in PMC: 2014 Jan 9.
Published in final edited form as: J Am Chem Soc. 2012 Dec 21;135(1):354–366. doi: 10.1021/ja3095558

Figure 2. Stalling factors for different systems.

Figure 2

Shown here are the (A) DNA primer, DNA template system with OAt esters and (B) different template backbone and leaving groups. The stalling factor is the ratio of polymerization rate from matched terminus to rate of extension from mis-matched terminus. Stalling factors are calculated for extension by the correct monomer (SG); by definition, SG = 1 for extension after a matched base pair. In (B), white is template 5uu with 4a-t; black is 5uu with 3a-t; hatched is 1tt with 4a-t; gray is 1tt with 3a-t (also shown in (A)).