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Acid-fast organisms from biopsy specimens of a man with leprosy, United States. Fite-stained sections show numerous acid-fast bacilli in the initial skin biopsy specimen (A) and in the biopsy specimen taken at relapse, 6 years after completion of treatment (B). Both specimens demonstrate the clumps of Mycobacterium leprae referred to as globi. In panel B, bacilli can be seen within a cutaneous nerve (arrows), a finding that is pathognomonic of M. leprae. Original magnification ×1,000.
