Table 2.

Mothers by initial diagnosis, and their progression (n=229), group II: mothers enrolled >1 year after birth of a neonatal lupus (NL)-affected child (n=126)

Initial diagnosis at enrolment	n1*	n2†	Diagnosis after follow-up	n	Mean time to diagnosis	Mean follow-up (years)	CHB‡	Rash§	Time from birth to latest follow-up
Asymptomatic	29	19	Asymptomatic	11	–	4.9	10	1	9
			Pauci-UAS	1	1	1.5	1	0	3.2
			Probable SS	2	4	8.1	2	0	11
			Definite SS	2	3	7.5	2	0	10
			SLE	2	8	10.6	2	0	12
			SLE/SS	1	5	10.5	1	0	14
Pauci-UAS	23	17	Pauci-UAS	10	–	4.5	8	2	9
			Poly-UAS	3	1	4.5	3	0	7
			Probable SS	1	4	5.7	1	0	20.2
			SLE	2	6	9.7	2	0	12
			SLE/SS	1	2	3.8	1	0	10.9
Poly-UAS	12	7	Poly-UAS	4	–	3.6	3	1	13
			Probable SS	1	3	8.3	0	1	10.2
			SLE/SS	2	3	10.2	2	0	12
Probable SS	35	21	Probable SS	16	–	5.5	11	5	13
			Definite SS	1	2	7	1	0	12
			SLE/SS	4	3	4.5	2	2	9
Definite SS	13	13	Definite SS	11	–	4.7	9	2	15
			SLE/SS	2	7	8.1	2	0	12
SLE	32	22	SLE	22	–	6.2	16	6	13
SLE/SS	39	27	SLE/SS	–		4.4	21	6	15

The maternal mean age at the birth of the NL child was 30 years in both groups (16–44 years). The ethnic distribution was: 74.1% Caucasian, 9.7% African–American, 8.4% Hispanic, 5.0% Asian and 2.8% unknown/unanswered. Of 229 mothers studied, 171 had at least 1 NL child with CHB and 58 only had an NL rash child.

^*n1, Total number of mothers who enrolled with specific diagnoses

^†n2, mothers who were followed for at least 6 months

^‡CHB, mothers who had a child with congenital heart block (CHB), or a child with CHB+rash

^§rash, mothers who had a child with NL rash only. SLE, systemic lupus erythematosus

SS, Sjögren syndrome

UAS, undifferentiated autoimmune syndrome. Extended rep