Table 4.

Frequency of genotypes in Research Registry for Neonatal Lupus (RRNL) mothers studied followed for at least 3 years^*

	Allelic frequency		p Value†	Genotypic frequency			p Value†
IL1a –889C/T (n=43):
Diagnosis	C	T		C/C	C/T	T/T
Asymptomatic to asymptomatic, pauci-UAS and SS (n=10)	16	4	0.75	6	4	0	1.0
Initial or progression to SLE (n=33)	49	17	18	13	2
TGFβ 869T/C (n=55):
Diagnosis	C	T		C/C	T/C	T/T
Asymptomatic to asymptomatic, pauci-UAS and SS (n=14)	16	12	0.03	4	8	2	0.03
Initial or progression to SLE (n=41)	27	55		6	15	20
TNFα –308G/A (n=58):
Diagnosis	G	A		G/G	G/A	A/A
Asymptomatic to asymptomatic, pauci-UAS and SS (n=15)	20	10	0.4	5	10	0	0.5
Initial or progression to SLE (n=43)	49	37		10	29	4

The genotype frequencies calculated for interleukin (IL)1α –889C/T, transforming growth factor (TGF)β 869T/C and tumour necrosis factor (TNF)α –308G/A were CC+CT vs TT, CC+TC vs TT, AA+GA vs GG, respectively. In addition, these three polymorphisms were compared to historical controls, there was an increased frequency of the IL1α –889(C/C) in systemic lupus erythematosus (SLE) (32% vs 55%, respectively, p=0.017), TGFβ 869(T/T) in SLE (49% vs 35% to 40%, respectively, p=not significant) and –308A allele of TNFα (AA+GA vs GG) in SLE (24% vs 77%, respectively; p<0.001).^6,9,30–32 Comparisons between the groups were performed by Fisher exact test. p<0.05 was considered significant.

^*Only Caucasian mothers were included in this analysis

^†p values for comparison of mothers with SLE vs asymptomatic mothers.

SS, Sjögren syndrome, UAS, undifferentiated autoimmune syndrome.