Table 3.
Unadjusted FTND Distributions by Genotype in the Treatment Seeking Smoker Cohort
| SNP | Major | Mean (SD) | Heterozygote | Mean (SD) | Minor | Mean (SD) | PF1 | r2 |
|---|---|---|---|---|---|---|---|---|
| rs10891552 | 754 | 5.27 (2.18) | 64 | 6.20 (2.10) | - | - | 0.001 | 1.32 |
| rs2975226 | 289 | 5.02 (2.20) | 345 | 5.49 (2.15) | 123 | 5.65 (2.22) | 0.006 | 1.32 |
| rs2652510 | 296 | 5.19 (2.21) | 377 | 5.47 (2.15) | 132 | 5.59 (2.19) | 0.030 | 0.87 |
| rs834829 | 405 | 5.18 (2.12) | 334 | 5.58 (2.23) | 69 | 5.12 (2.29) | 0.010 | 0.82 |
| rs2652511 | 300 | 5.06 (2.21) | 377 | 5.49 (2.13) | 124 | 5.59 (2.20) | 0.016 | 1.04 |
1
Genetic model of ANOVA is dominant or additive for rs10891552, heterotic for rs834829, and additive for SLC6A3 SNPs. The genotype(s) associated with increased FTND scores can be inferred by inspection.