Table 3.
Effect of M.sapientum seed extract on charcoal meal stimulated gastrointestinal transit in mice
Dose (p.o) | Mean intestinal length (cm) | Mean distance traveled by charcoal (cm) | % GI transit | |
---|---|---|---|---|
Group I | 0.4 ml/mouse | 68.4±0.98 | 50.4±1.18 | 73.86±3.57 |
Group II | 0.1 mg/kg | 63.2±1.61 | 20±1.04** | 31.62±1.32** |
Group III | 100 mg/kg | 63.8±2.41 | 35±0.91** | 55.05±1.39** |
Group IV | 200 mg/kg | 66.2±2.60 | 24.8±1.61** | 37.82±3.04** |
Values are presented as mean±SEM, (n = 5); p<0.001, student's t test compared to control. Group I animals received vehicle (1% Tween 80 in water), Group II received atropine sulfate 0.1 mg/kg body weight, Group III and Group IV were treated with 100 and 200 mg/kg body weight (p.o.) of the MMSS