Table 3A.

Apoptosis induction by 4-HPR

		CCRF-CEM	Nalm-6
Time	Concentration	Apoptosis %
24 hour	Control	0.57 ± 0.25	0.33 ± 0.13
	1 µM	3.67 ± 1.82	6.72 ± 2.44
	2.5 µM	9 ± 4.1	11.8 ± 3.02
	5 µM	11.4 ± 2.66*	12.72 ± 1.38*
	7.5 µM	15.97 ± 1.81*	9.22 ± 2.77
	10 µM	10.86 ± 0.98*	9.7 ± 1.56*
48 hour	Control	0.71 ± 0.19	0.44 ± 0.075
	1 µM	10.95 ± 1.39*	9.55 ± 0.95*
	2.5 µM	13.99 ± 0.53*	10.91 ± 3.45
	5 µM	16.62 ± 2.44*	9.67 ± 1.24*
	7.5 µM	10.09 ± 5.21	8.67 ± 4.16
	10 µM	11.3 ± 1.58*	20.12 ± 9.5

Apoptosis induction by (3A) 4-HPR in ALL cell lines.

Results (mean±S.E.M. of three separate experiments) are the percentage of cells positive for annexin V. P-values are for individual treatment groups compared to control

^*p < 0.05