Table 3B.

Apoptosis induction by 1α,25(OH)₂D₃

		CCRF-CEM	Nalm-6
Time	Concentration	Apoptosis %
24 hour	Control	0.57 ± 0.25	0.33 ± 0.13
	0.1 nM	3.5 ± 1.65	2.29 ± 0.77
	1 nM	4.91 ± 2.18	3.56 ± 0.22*
	10 nM	5.78 ± 2.19	4.46 ± 2.36
	100 nM	9.71 ± 1.9*	7.81 ± 2.39
48 hour	Control	0.71 ± 0.19	0.44 ± 0.075
	0.1 nM	3.78 ± 1.19	5.52 ± 0.87*
	1 nM	6.24 ± 1.42	3.86 ± 0.53*
	10 nM	8.52 ± 1.32*	3.58 ± 1.91
	100 nM	40.89 ± 8.96*	15.47 ± 3.4*

Apoptosis induction by (3B) 1α,25(OH)₂D₃ in ALL cell lines

Results (mean±S.E.M. of three separate experiments) are the percentage of cells positive for annexin V. P-values are for individual treatment groups compared to control

^*p < 0.05