Table 3.
Effect of Vinblastine and LiCl alone or in combination on cell cycle progression of DU145 cells
| Condition | SubG1 (%) | G1 (%) | S (%) | G2/M (%) |
|---|---|---|---|---|
| Control | 1.81±0.45 | 62.89±2.37 | 15.13±1.40 | 19.73±1.22 |
| IC 50 = 20 mM LiCl | 4.93±0.35 | 40.30±8.18a *** | 23.47±2.52a * | 28.85±3.18 |
| 1.5 nM Vin | 22.66±1.60a *** | 47.32±8.18 | 18.06±0.68 | 20.64±2.98 |
| 1.5 nM Vin + IC 50 LiCl | 17.30±3.24a *** / c ** | 31.58±4.58a ** | 20.63±1.96 | 32.56±3.12a * / d * |
| IC 50 = 5.0 nM Vin | 21.40±2.45a *** | 16.488±3.63a *** | 12.46±2.45 | 51.70±1.23a *** |
| IC 50 (Vin + LiCl ) | 11.41±1.90a / b * | 12.22±4.60a *** / c * | 14.62±1.75c * | 62.37±4.00a *** / c *** |
compared to control
compared to 2.5 nM
compared to 20 mM
compared to 1.5 nM
p<0.05
p<0.01
p<0.001. Values are expressed as mean±SEM (n ≥ 3)