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. 2012 Apr-Jun;4(2):75–87.

Table 3.

Effect of Vinblastine and LiCl alone or in combination on cell cycle progression of DU145 cells

Condition SubG1 (%) G1 (%) S (%) G2/M (%)
Control 1.81±0.45 62.89±2.37 15.13±1.40 19.73±1.22
IC 50 = 20 mM LiCl 4.93±0.35 40.30±8.18a *** 23.47±2.52a * 28.85±3.18
1.5 nM Vin 22.66±1.60a *** 47.32±8.18 18.06±0.68 20.64±2.98
1.5 nM Vin + IC 50 LiCl 17.30±3.24a *** / c ** 31.58±4.58a ** 20.63±1.96 32.56±3.12a * / d *
IC 50 = 5.0 nM Vin 21.40±2.45a *** 16.488±3.63a *** 12.46±2.45 51.70±1.23a ***
IC 50 (Vin + LiCl ) 11.41±1.90a / b * 12.22±4.60a *** / c * 14.62±1.75c * 62.37±4.00a *** / c ***
a

compared to control

b

compared to 2.5 nM

c

compared to 20 mM

d

compared to 1.5 nM

*

p<0.05

**

p<0.01

***

p<0.001. Values are expressed as mean±SEM (n ≥ 3)