Figure 4. .

Specialized pro-resolution mediators (SPM) and miRNA-mediated resolution of HSV-induced ocular inflammation: speculations. The provision of SPM during HSK may result in changes in levels of various miRNAs associated with resolution. SPM could increase expression of miR-21 and miR-208a both of which induce anti-inflammatory cytokine, IL-10. SPM can also increase miR-146b expression and miR-146 lowers levels of IL-8, a chemokine crucial for neutrophil recruitment to eyes. miR-292-2 induced by SPM gives positive feedback for more SPM production. The administration of SPM may also lower levels of miR-132 and miR-155 involved in CV and inflammation, respectively.